Its a big world - so I do it Lik this:
1) When I first go on - I do my standard checklist (test chat, test pics, test Audio / Video Options, draw each weapon and fire / use it once) - stuff that you do everyday.
2) I pick the zone which I'm gonna test for that day (PR, SvS, Or Specific Glitches I've Herd / Know). and Do a once around (or sail around) watching just for standard Video bloopers.
3) I then do everything possible within that area with all the Glitches I know to see what I can break and report each find on the ? mark.
(for example - me and Zep one night for 1/2 an hour just ran around trying to find all the NPC players of the new PR - when June was 'missing', but also reported missing signs and out of place items - another night I just ran into the Graveyard there 50 times as it was making me crash - sometimes - when coming from the north side and running in... trying different ways to crash)
Well - thats how I do it