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Since you can only get 100 rep per weapon per kill, almost any place is good. My favorite is Timothy Dartan on PDF beach. I use dagger to draw him in, take his health to about 2/3, then switch to doll for a life drain, then to pistol and take his health to about 1/3, then life drain again, then finish with cutlass. extra life drains if needed. Usually get about 280 to 350 rep, depending on the level of Tim.
One thing though, I keep my skill points at only one point per skill, lower damage means it takes more hits to kill him, which means higher rep. Also, don't use combos if you can avoid it.
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