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Originally Posted by Stormhawk
I don't. It can save you from dying (if it is maxed) when your health is low and you are fighting enemies (it can only save you from injured level 31+ enemies though) since it does not kill you. It also helps clean a ship during flagship battles. 
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Nothing worse than taking your health down when facing a tough enemy (like a level 30+ enemy), and Desolation wont kill them, you'd have to cast it several times (and die while they beat you senseless). Unless you beef it up with extra points (that you will find are much more useful elsewheres).
For something that takes so long to charge, hurts the caster, and doesnt take out any enemies... seems like more of a hindrance than a help.
Sure does look cool though.